| Item type |
学術雑誌論文 / Journal Article_02(1) |
| 公開日 |
2009-05-15 |
| タイトル |
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タイトル |
Neuronal RNA oxidation is a prominent feature of dementia with Lewy bodies |
|
言語 |
en |
| 言語 |
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|
言語 |
eng |
| 資源タイプ |
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資源タイプ |
journal article |
| 著者 |
布村, 明彦
Chiba, S
Kosaka, K
Takeda, A
Castellani, RJ
Smith, MA
Perry, G
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| 著者 ローマ字 |
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Nunomura, Akihiko |
| 著者 ローマ字 |
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en |
| 書誌情報 |
Neuroreport
巻 13,
号 16,
p. 2035-2039,
発行日 2002-11-01
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| ISSN |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
0959-4965 |
| リンクURL |
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内容記述タイプ |
Other |
|
内容記述 |
http://journals.lww.com/neuroreport/pages/default.aspx | http://journals.lww.com/neuroreport/pages/default.aspx |
| 抄録 |
|
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内容記述タイプ |
Abstract |
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内容記述 |
An in situ approach was used to identify the oxidized nucleoside, 8-hydroxyguanosine in brains of dementia with Lewy bodies. Neurons with marked immunoreaction of 8-hydroxyguanosine in the cytoplasm were widely distributed in the hippocampal region and temporal neocortex. Relative intensity measurements of neuronal 8-hydroxyguanosine immunoreactivity showed that there was a significant increase in nucleic acid oxidation in dementia with Lewy bodies compared with controls. Treatment with nuclease (DNase or RNase) before the immunostaining demonstrated that RNA was a major site of nucleic acid oxidation. Together with the previously reported RNA oxidation in vulnerable neurons in Alzheimer and Parkinson diseases, neuronal RNA oxidation in dementia with Lewy bodies might represent one of the fundamental abnormalities in age-associated neurodegenerative diseases. |
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言語 |
en |
| 注記 |
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内容記述タイプ |
Other |
|
注記 |
This is a non-final version of an article published in final form in Nunomura, Akihiko ; Chiba, Shigeru ; Kosaka, Kenji ; Takeda, Atsushi ; Castellani, Rudy J. ; Smith, Mark A. ; Perry, George, Neuronal RNA oxidation is a prominent feature of dementia with Lewy bodies, Neuroreport 13(16), NOV 2002, pp. 2035-2039
\nauthor |
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言語 |
en |
| 資源タイプ |
|
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内容記述タイプ |
Other |
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資源タイプ |
text |
| 著者版フラグ |
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出版タイプ |
AM |
| フォーマット |
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内容記述タイプ |
Other |
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内容記述 |
application/pdf |
| ID(XooNIps) |
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12438921 |
| 閲覧数(XooNIps) |
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| ダウンロード数(XooNIps) |
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1098 |
2140.pdf (344.3 kB)
