{"created":"2023-06-19T11:21:20.399882+00:00","id":1525,"links":{},"metadata":{"_buckets":{"deposit":"e9c33dd1-db2d-4b84-a288-c184650c3e1b"},"_deposit":{"created_by":3,"id":"1525","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"1525"},"status":"published"},"_oai":{"id":"oai:asahikawa-med.repo.nii.ac.jp:00001525","sets":["7","7:24"]},"author_link":["4890","4891","4892","4893","4894","4895"],"item_5_biblio_info_21":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2005-11-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"11","bibliographicPageEnd":"960","bibliographicPageStart":"955","bibliographicVolumeNumber":"35","bibliographic_titles":[{"bibliographic_title":"Surgery Today"}]}]},"item_5_description_25":{"attribute_name":"リンクURL","attribute_value_mlt":[{"subitem_description":"http://dx.doi.org/10.1007/s00595-005-3074-8 | http://dx.doi.org/10.1007/s00595-005-3074-8","subitem_description_type":"Other"}]},"item_5_description_33":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Purpose. Hematopoietic stem cells (SC) are though to have the potential to differentiate into hepatocytes; however, this potential has not been reported for cryopreserved SCs. We investigated if cryopreserved bone marrow cells (BMCs) from F344 rats (F344) can induce the growth of albumin-producing hepatocytes in the livers of congenic Nagase’s analbuminemic rats (F344alb).  Methods. F344 BMCs were cryopreserved in University of Wisconsin (UW) solution containing 10% fetal bovine serum and 12% dimethylsulfoxide, at ?80℃. After thawing, 20 x 10^7 cells were infused via the portal vein into the livers of F344alb immediately after 70% hepatectomy (PH). We examined the recipient livers for albumin positive (alb+) hepatocytes and albumin mRNA and measured the serum albumin levels 4 weeks later. Results. Single and double alb+ hepatocytes were occasionally seen in the F344alb livers without the BMC transplantation. However, clusters consisting of more than three alb+ hepatocytes were seen in the livers of recipients transplanted with the cryopreserved BMCs after PH, the same as in the livers transplanted with freshly-isolated BMCs. Normal albumin mRNA was detected in the recipient livers, and the serum albumin levels were increased. Conclusion. Cryopreserved F344 BMCs can induce the growth of alb+ hepatocytes after transplantion in the F344alb liver after PH.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_5_description_36":{"attribute_name":"注記","attribute_value_mlt":[{"subitem_description":"The original publication is available at springerlink.com author","subitem_description_language":"en","subitem_description_type":"Other"}]},"item_5_description_37":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"text","subitem_description_type":"Other"}]},"item_5_description_41":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_5_relation_24":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1007/s00595-005-3074-8","subitem_relation_type_select":"DOI"}}]},"item_5_source_id_22":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0941-1291","subitem_source_identifier_type":"ISSN"}]},"item_5_text_44":{"attribute_name":"ID(XooNIps)","attribute_value_mlt":[{"subitem_text_value":"16249851"}]},"item_5_text_54":{"attribute_name":"閲覧数(XooNIps)","attribute_value_mlt":[{"subitem_text_value":"2838"}]},"item_5_text_55":{"attribute_name":"ダウンロード数(XooNIps)","attribute_value_mlt":[{"subitem_text_value":"1053"}]},"item_5_text_7":{"attribute_name":"著者 ローマ字","attribute_value_mlt":[{"subitem_text_value":"Inagaki, Mitsuhiro"},{"subitem_text_language":"en"}]},"item_5_version_type_38":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"稲垣, 光裕","creatorNameLang":"ja"},{"creatorName":"イナガキ, ミツヒロ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"4890","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Arikura, J","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"4891","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Huiling, X"}],"nameIdentifiers":[{"nameIdentifier":"4892","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yan, X","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"4893","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ogawa, K"}],"nameIdentifiers":[{"nameIdentifier":"4894","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kasai, S","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"4895","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2021-07-06"}],"displaytype":"detail","filename":"2038.pdf","filesize":[{"value":"408.0 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"2038.pdf","url":"https://asahikawa-med.repo.nii.ac.jp/record/1525/files/2038.pdf"},"version_id":"09399d3e-3c61-46ad-9d37-8f8af83af2da"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Albumin-producing hepatocytes derived from cryopreserved F344 rat bone marrow cells transplanted in the livers of congenic Nagase's analbuminemic rats.","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Albumin-producing hepatocytes derived from cryopreserved F344 rat bone marrow cells transplanted in the livers of congenic Nagase's analbuminemic rats.","subitem_title_language":"en"}]},"item_type_id":"5","owner":"3","path":["7","24"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2009-04-24"},"publish_date":"2009-04-24","publish_status":"0","recid":"1525","relation_version_is_last":true,"title":["Albumin-producing hepatocytes derived from cryopreserved F344 rat bone marrow cells transplanted in the livers of congenic Nagase's analbuminemic rats."],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2024-04-25T07:53:09.870613+00:00"}