| Item type |
学術雑誌論文 / Journal Article_02(1) |
| 公開日 |
2009-04-24 |
| タイトル |
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タイトル |
Albumin-producing hepatocytes derived from cryopreserved F344 rat bone marrow cells transplanted in the livers of congenic Nagase's analbuminemic rats. |
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言語 |
en |
| 言語 |
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|
言語 |
eng |
| 資源タイプ |
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資源タイプ |
journal article |
| 著者 |
稲垣, 光裕
Arikura, J
Huiling, X
Yan, X
Ogawa, K
Kasai, S
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| 著者 ローマ字 |
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Inagaki, Mitsuhiro |
| 著者 ローマ字 |
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en |
| 書誌情報 |
Surgery Today
巻 35,
号 11,
p. 955-960,
発行日 2005-11-01
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| ISSN |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
0941-1291 |
| DOI |
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関連タイプ |
isVersionOf |
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識別子タイプ |
DOI |
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関連識別子 |
10.1007/s00595-005-3074-8 |
| リンクURL |
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内容記述タイプ |
Other |
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内容記述 |
http://dx.doi.org/10.1007/s00595-005-3074-8 | http://dx.doi.org/10.1007/s00595-005-3074-8 |
| 抄録 |
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内容記述タイプ |
Abstract |
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内容記述 |
Purpose. Hematopoietic stem cells (SC) are though to have the potential to differentiate into hepatocytes; however, this potential has not been reported for cryopreserved SCs. We investigated if cryopreserved bone marrow cells (BMCs) from F344 rats (F344) can induce the growth of albumin-producing hepatocytes in the livers of congenic Nagase’s analbuminemic rats (F344alb). Methods. F344 BMCs were cryopreserved in University of Wisconsin (UW) solution containing 10% fetal bovine serum and 12% dimethylsulfoxide, at ?80℃. After thawing, 20 x 10^7 cells were infused via the portal vein into the livers of F344alb immediately after 70% hepatectomy (PH). We examined the recipient livers for albumin positive (alb+) hepatocytes and albumin mRNA and measured the serum albumin levels 4 weeks later. Results. Single and double alb+ hepatocytes were occasionally seen in the F344alb livers without the BMC transplantation. However, clusters consisting of more than three alb+ hepatocytes were seen in the livers of recipients transplanted with the cryopreserved BMCs after PH, the same as in the livers transplanted with freshly-isolated BMCs. Normal albumin mRNA was detected in the recipient livers, and the serum albumin levels were increased. Conclusion. Cryopreserved F344 BMCs can induce the growth of alb+ hepatocytes after transplantion in the F344alb liver after PH. |
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言語 |
en |
| 注記 |
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内容記述タイプ |
Other |
|
注記 |
The original publication is available at springerlink.com author |
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言語 |
en |
| 資源タイプ |
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内容記述タイプ |
Other |
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資源タイプ |
text |
| 著者版フラグ |
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出版タイプ |
AM |
| フォーマット |
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内容記述タイプ |
Other |
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内容記述 |
application/pdf |
| ID(XooNIps) |
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16249851 |
| 閲覧数(XooNIps) |
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| ダウンロード数(XooNIps) |
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1053 |
2038.pdf (408.0 kB)
