{"created":"2023-06-19T11:20:08.255958+00:00","id":144,"links":{},"metadata":{"_buckets":{"deposit":"5763e04b-1def-4b38-a9fe-318169bcfcc6"},"_deposit":{"created_by":3,"id":"144","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"144"},"status":"published"},"_oai":{"id":"oai:asahikawa-med.repo.nii.ac.jp:00000144","sets":["7","7:24"]},"author_link":["91","92","93","94","95","96","97","98","99","100","101","102","103"],"item_5_biblio_info_21":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2005-09-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"9","bibliographicPageEnd":"997","bibliographicPageStart":"992","bibliographicVolumeNumber":"11","bibliographic_titles":[{"bibliographic_title":"NATURE MEDICINE"}]}]},"item_5_description_25":{"attribute_name":"リンクURL","attribute_value_mlt":[{"subitem_description":"http://www.nature.com/nm/journal/v11/n9/full/nm1294.html | http://www.nature.com/nm/journal/v11/n9/full/nm1294.html","subitem_description_type":"Other"}]},"item_5_description_33":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Hypoxia inducible factor-1 (HIF-1) is considered a crucial mediator of the cellular response to hypoxia through its regulation of genes that control angiogenesis^1, ^2, ^3, ^4. It represents an attractive therapeutic target^5, ^6 in colon cancer, one of the few tumor types that shows a clinical response to antiangiogenic therapy^7. But it is unclear whether inhibition of HIF-1 alone is sufficient to block tumor angiogenesis^8, ^9. In HIF-1_α knockdown DLD-1 colon cancer cells (DLD-1^HIF-kd), the hypoxic induction of vascular endothelial growth factor (VEGF) was only partially blocked. Xenografts remained highly vascularized with microvessel densities identical to DLD-1 tumors that had wild-type HIF-1_α (DLD-1^HIF-wt). In addition to the preserved expression of VEGF, the proangiogenic cytokine interleukin (IL)-8 was induced by hypoxia in DLD-1^HIF-kd but not DLD-1^HIF-wt cells. This induction was mediated by the production of hydrogen peroxide and subsequent activation of NF-_KB. Furthermore, the KRAS oncogene, which is commonly mutated in colon cancer, enhanced the hypoxic induction of IL-8. A neutralizing antibody to IL-8 substantially inhibited angiogenesis and tumor growth in DLD-1^HIF-kd but not DLD-1^HIF-wt xenografts, verifying the functional significance of this IL-8 response. Thus, compensatory pathways can be activated to preserve the tumor angiogenic response, and strategies that inhibit HIF-1α may be most effective when IL-8 is simultaneously targeted.","subitem_description_type":"Abstract"}]},"item_5_description_36":{"attribute_name":"注記","attribute_value_mlt":[{"subitem_description":"author","subitem_description_type":"Other"}]},"item_5_description_37":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"text","subitem_description_type":"Other"}]},"item_5_description_41":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_5_relation_24":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1038/nm1294","subitem_relation_type_select":"DOI"}}]},"item_5_source_id_22":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1078-8956","subitem_source_identifier_type":"ISSN"}]},"item_5_text_16":{"attribute_name":"出版社 ローマ字","attribute_value_mlt":[{"subitem_text_value":"NATURE PUBLISHING GROUP"}]},"item_5_text_44":{"attribute_name":"ID(XooNIps)","attribute_value_mlt":[{"subitem_text_value":"16127434"}]},"item_5_text_54":{"attribute_name":"閲覧数(XooNIps)","attribute_value_mlt":[{"subitem_text_value":"2833"}]},"item_5_text_55":{"attribute_name":"ダウンロード数(XooNIps)","attribute_value_mlt":[{"subitem_text_value":"1893"}]},"item_5_text_7":{"attribute_name":"著者 ローマ字","attribute_value_mlt":[{"subitem_text_value":"Mizukami, Yusuke"}]},"item_5_version_type_38":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"水上, 裕輔"},{"creatorName":"ミズカミ, ユウスケ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"91","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Jo, WS"}],"nameIdentifiers":[{"nameIdentifier":"92","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Duerr, EM"}],"nameIdentifiers":[{"nameIdentifier":"93","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Gala, M"}],"nameIdentifiers":[{"nameIdentifier":"94","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Li, JN"}],"nameIdentifiers":[{"nameIdentifier":"95","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Zhang, XB"}],"nameIdentifiers":[{"nameIdentifier":"96","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Zimmer, MA"}],"nameIdentifiers":[{"nameIdentifier":"97","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Iliopoulos, O"}],"nameIdentifiers":[{"nameIdentifier":"98","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Zukerberg, LR"}],"nameIdentifiers":[{"nameIdentifier":"99","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kohgo, Y"}],"nameIdentifiers":[{"nameIdentifier":"100","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Lynch, MP"}],"nameIdentifiers":[{"nameIdentifier":"101","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Rueda, BR"}],"nameIdentifiers":[{"nameIdentifier":"102","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Chung, DC"}],"nameIdentifiers":[{"nameIdentifier":"103","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2021-07-06"}],"displaytype":"detail","filename":"224.pdf","filesize":[{"value":"787.9 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"224.pdf","url":"https://asahikawa-med.repo.nii.ac.jp/record/144/files/224.pdf"},"version_id":"5ee5c176-8799-4947-a8d6-ad22de840f67"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Induction of interleukin-8 preserves the angiogenic response in HIF-1 alpha-deficient colon cancer cells","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Induction of interleukin-8 preserves the angiogenic response in HIF-1 alpha-deficient colon cancer cells","subitem_title_language":"en"}]},"item_type_id":"5","owner":"3","path":["6","7","24"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2007-02-14"},"publish_date":"2007-02-14","publish_status":"0","recid":"144","relation_version_is_last":true,"title":["Induction of interleukin-8 preserves the angiogenic response in HIF-1 alpha-deficient colon cancer cells"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2024-04-19T11:43:22.885662+00:00"}