| Item type |
学術雑誌論文 / Journal Article_02(1) |
| 公開日 |
2009-03-11 |
| タイトル |
|
|
タイトル |
The role of CCL22/macrophage-derived chemokine in allergic rhinitis |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| 資源タイプ |
|
|
資源タイプ |
journal article |
| 著者 |
立野, 正敏
Yanai, M
Sato, K
Aoki, N
Takiyama, Y
Oikawa, K
Kobayashi, H
Kimura, S
Harabuchi, Y
|
| 著者 ローマ字 |
|
|
|
Tateno, Masatoshi |
| 書誌情報 |
Clinical Immunology
巻 125,
号 3,
p. 291-298,
発行日 2007-12-01
|
| ISSN |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
1521-6616 |
| DOI |
|
|
関連タイプ |
isVersionOf |
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
10.1016/j.clim.2007.08.002 |
| リンクURL |
|
|
内容記述タイプ |
Other |
|
内容記述 |
http://dx.doi.org/10.1016/j.clim.2007.08.002 | http://dx.doi.org/10.1016/j.clim.2007.08.002 |
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Dendritic Cells (DCs) are considered to be the most powerful antigen-presenting cells (APCs). DCs are thought to be associated with Th1 or Th2 polarization and with polarization-induced disease such as atopic dermatitis, asthma and allergic rhinitis, but its mechanism is not well known. In this study, we analyzed the mRNA expression of DCs between birch pollen allergic rhinitis and healthy controls by using cDNA array. We found that the expressions of CCL22/macrophage derived chemokine (MDC) differed significantly. We also revealed that CCL22/MDC production was higher in patients than in healthy donors. By chemotaxis assay, CCL22/MDC can enhance the migration of patient’s T cells rather than those of healthy controls. Surface marker analysis of migrated cells revealed that the most of migrated cells expressed CCR4, which were considered to be Th2 cells. Furthermore, CD1a^+CD83^+ cells located in the nasal mucosa expressed CCL22/MDC in vivo. To the best of our knowledge, this is the first report clearly indicating the role of CCL22/MDC in allergic rhinitis. |
| 注記 |
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内容記述タイプ |
Other |
|
注記 |
author |
| 資源タイプ |
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内容記述タイプ |
Other |
|
資源タイプ |
text |
| 著者版フラグ |
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|
出版タイプ |
AM |
| フォーマット |
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|
内容記述タイプ |
Other |
|
内容記述 |
application/pdf |
| ID(XooNIps) |
|
|
|
17911044 |
| 閲覧数(XooNIps) |
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| ダウンロード数(XooNIps) |
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|
2215 |
1627.pdf (834.0 kB)
