| Item type |
学術雑誌論文 / Journal Article_02(1) |
| 公開日 |
2009-03-11 |
| タイトル |
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タイトル |
Recovery of susceptibility to penicillin G in clinical isolates of Streptococcus pneumoniae despite increased accumulation of pbp gene alterations |
|
言語 |
en |
| 言語 |
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|
言語 |
eng |
| 資源タイプ |
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資源タイプ |
journal article |
| 著者 |
大崎, 能伸
Tachibana, M
Awaya, T
Kuroki, M
Ito, Y
|
| 著者 ローマ字 |
|
|
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Ohsaki, Yoshinobu |
| 書誌情報 |
International Journal of Antimicrobial Agents
巻 32,
号 5,
p. 427-431,
発行日 2008-11-01
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| ISSN |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
0924-8579 |
| DOI |
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関連タイプ |
isVersionOf |
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識別子タイプ |
DOI |
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関連識別子 |
10.1016/j.ijantimicag.2008.05.002 |
| リンクURL |
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内容記述タイプ |
Other |
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内容記述 |
http://dx.doi.org/10.1016/j.ijantimicag.2008.05.002 | http://dx.doi.org/10.1016/j.ijantimicag.2008.05.002 |
| 抄録 |
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内容記述タイプ |
Abstract |
|
内容記述 |
Two hundred consecutive clinical isolates of S. pneumoniae in 2005 and 2006 wereanalyzed for susceptibility to antimicrobials, pbp alterations and macrolide resistant gene expressions (2007 analysis). The results were compared with our previous data (2003 analysis). The average minimum inhibitory concentration (MIC) of penicillin G (PEN-G) in isolates with 1a^m/2x^m/2b^m decreased from 1.135±0.503 mg/L in the 2003 analysis to 0.872±0.540 mg/L in the 2007 analysis (p=0.0046). Isolates with 1a^m/2x^m/2b^m increased from 30.5% to 32.3% but the difference was not statistically significant (p=0.6979). Isolates with a MIC of clarithromycin ≥1.0 mg/L increased from 65.9% to 80.0% (p=0.0005). Isolates with ermB expression increased from 46.6% to 62.6% (p=0.0004). We concluded that the decrease of penicillin resistance of S. pneumoniae did not correlate with a decrease in pbp mutations; on the contrary, isolates with pbp mutations increased. A decrease of penicillin resistance in S. pneumoniae with the pbp mutation seemed to explain our present results about the recovery of penicillin susceptibility. Our results suggested that the spread of mutated pbp genes among S. pneumoniae itself is not responsible for the acquisition of the penicillin-resistant phenotype. Use of β-lactams, especially oral cephalosporins, seems to be responsible for the acquisition of penicillin resistance. |
| 注記 |
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内容記述タイプ |
Other |
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注記 |
author |
| 資源タイプ |
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内容記述タイプ |
Other |
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資源タイプ |
text |
| 著者版フラグ |
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出版タイプ |
AM |
| フォーマット |
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内容記述タイプ |
Other |
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内容記述 |
application/pdf |
| ID(XooNIps) |
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18715767 |
| 閲覧数(XooNIps) |
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| ダウンロード数(XooNIps) |
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944 |
1622.pdf (537.3 kB)
