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CD26: A novel treatment target for T-cell lymphoid malignancies? (Review)
https://asahikawa-med.repo.nii.ac.jp/records/1334
https://asahikawa-med.repo.nii.ac.jp/records/133459ea58ed-e306-4018-886a-7c5ba4b1bdb7
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
1619.pdf (10.0 MB)
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| Item type | 学術雑誌論文 / Journal Article_02(1) | |||||||||||
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| 公開日 | 2009-03-11 | |||||||||||
| タイトル | ||||||||||||
| タイトル | CD26: A novel treatment target for T-cell lymphoid malignancies? (Review) | |||||||||||
| 言語 | en | |||||||||||
| 言語 | ||||||||||||
| 言語 | eng | |||||||||||
| 資源タイプ | ||||||||||||
| 資源タイプ | journal article | |||||||||||
| 著者 |
佐藤, 一也
× 佐藤, 一也
× Dang, NH
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| 著者 ローマ字 | ||||||||||||
| Sato, Kazuya | ||||||||||||
| 書誌情報 |
International Journal Of Oncology 巻 22, 号 3, p. 481-497, 発行日 2003-01-01 |
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| ISSN | ||||||||||||
| 収録物識別子タイプ | ISSN | |||||||||||
| 収録物識別子 | 1019-6439 | |||||||||||
| 抄録 | ||||||||||||
| 内容記述タイプ | Abstract | |||||||||||
| 内容記述 | CD26 is a surface glycoprotein with intrinsic dipeptidyl peptidase IV (DPPIV) enzyme activity with multiple biological roles, including being intricately involved in immunoregulationas a T-call activation molecule and as a regulator of chemokine function. T-cell lymphoid malignancies represent a hetrogeneous group of diseases that aew generally aggressive and are for the most part resistant to current treatment modalities. Previous studies showed that CD26 is expressed on selected T-cell neoplasms, suggesting a potential role for CD26 in tumor development. We review herein recent classification schemes for T-cell lymphoid malignancies that take into accoung various facets of their clinical presentation. In addition, we discuss findings supporting the conclusion that CD26 has an essential role in human T-cell activation, as well as its ability to regulate the biological effects of selected chemokines through its DPPIV activity. Finally, we will present recent work from our laboratory that indicates a potenrial role for CD26 as a moleculatar target for novel treatment modalities for T-cell lymphoid malignancies. | |||||||||||
| 注記 | ||||||||||||
| 内容記述タイプ | Other | |||||||||||
| 注記 | publisher | |||||||||||
| 資源タイプ | ||||||||||||
| 内容記述タイプ | Other | |||||||||||
| 資源タイプ | text | |||||||||||
| フォーマット | ||||||||||||
| 内容記述タイプ | Other | |||||||||||
| 内容記述 | application/pdf | |||||||||||
| ID(XooNIps) | ||||||||||||
| 12579300 | ||||||||||||
| 閲覧数(XooNIps) | ||||||||||||
| ダウンロード数(XooNIps) | ||||||||||||
| 813 | ||||||||||||
