{"created":"2023-06-19T11:21:01.048073+00:00","id":1137,"links":{},"metadata":{"_buckets":{"deposit":"a5eee7d2-546e-4a69-b608-5bab70f12bd3"},"_deposit":{"created_by":3,"id":"1137","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"1137"},"status":"published"},"_oai":{"id":"oai:asahikawa-med.repo.nii.ac.jp:00001137","sets":["7","7:23"]},"author_link":["3654","3655"],"item_5_biblio_info_21":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2008-03-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"29","bibliographicPageStart":"18","bibliographicVolumeNumber":"5","bibliographic_titles":[{"bibliographic_title":"分子消化器病"}]}]},"item_5_description_33":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"NOははじめて発見されたガス状生理活性物質であり、正常腸管において血管内皮や神経で構成型NO合成酵素によって微量のNOが産生され、炎症性腸疾患の粘膜炎症部位において誘導型NO合成酵素によって大量のNOがつくられることが数多くの研究から支持されている。炎症性腸疾患動物モデルにおいてNO合成酵素阻害薬やノックアウトマウスを使用した研究から、構成型NOは腸炎の改善因子であり、誘導型NOは改善だけでなく腸炎増悪因子、発癌因子でもあることが多くの実験から明らかとなりつつある。炎症性腸疾患におけるNOの役割を理解するうえで、NO合成酵素の遺伝子多型、アルギニン代謝などを中心とした研究が役立つ可能性がある。","subitem_description_language":"ja","subitem_description_type":"Abstract"}]},"item_5_description_36":{"attribute_name":"注記","attribute_value_mlt":[{"subitem_description":"出版社版","subitem_description_type":"Other"}]},"item_5_description_37":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"text","subitem_description_type":"Other"}]},"item_5_description_41":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_5_source_id_22":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1348-995X","subitem_source_identifier_type":"PISSN"}]},"item_5_text_44":{"attribute_name":"ID(XooNIps)","attribute_value_mlt":[{"subitem_text_value":"2008163341"}]},"item_5_text_54":{"attribute_name":"閲覧数(XooNIps)","attribute_value_mlt":[{"subitem_text_value":"1605"}]},"item_5_text_55":{"attribute_name":"ダウンロード数(XooNIps)","attribute_value_mlt":[{"subitem_text_value":"696"}]},"item_5_text_7":{"attribute_name":"著者 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