{"created":"2023-06-19T11:20:57.547312+00:00","id":1062,"links":{},"metadata":{"_buckets":{"deposit":"01e15ae8-ca53-4cc0-99f3-362babc81992"},"_deposit":{"created_by":3,"id":"1062","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"1062"},"status":"published"},"_oai":{"id":"oai:asahikawa-med.repo.nii.ac.jp:00001062","sets":["7","7:23"]},"author_link":["3339","3340","3341","3342","3343"],"item_5_biblio_info_21":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2005-10-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"158","bibliographicPageStart":"155","bibliographicVolumeNumber":"30","bibliographic_titles":[{"bibliographic_title":"膝"}]}]},"item_5_description_33":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"著者等はこれまでにヒト新生児関節軟骨細胞がin vitroにおいてユニークな免疫調節能を示すことを報告してきたが、今回は抗炎症作用が確認されているヒアルロン酸のリンパ球増殖調節作用について検討した。健常人より末梢血単核球(PBMC)を分離、Magnetic cell sorting systemを用いてCD4+CD14-Tリンパ球を分離して、PBMCとCD4+CD14-Tリンパ球はCD28とCD3を刺激してポリクローナルに活性化させて材料とした。ポリクローナルに活性化させたPBMCとCD4+CD14-Tリンパ球に分子量80万のヒアルロン酸(HA)を0?37.5%(1.25?3.75mg/ml)添加して培養した。リン酸緩衝液をネガティブコントロールとして活性化後2・3・4・5日目の細胞増殖を[3H]サイミジン取り込み試験で測定し、同時に倒立顕微鏡下に細胞増殖形態を観察した。その結果、HAは1.25?3.75mg/ml濃度においてCD4+CD14-Tリンパ球増殖を全観察期間において有意に抑制した。以上より健常軟骨細胞は組織特異的抗原を発現しつつも関節液・関節軟骨中のヒアルロン酸によって免疫サーベイランスから逃れている可能性が示唆された。","subitem_description_language":"ja","subitem_description_type":"Abstract"}]},"item_5_description_36":{"attribute_name":"注記","attribute_value_mlt":[{"subitem_description":"出版社版","subitem_description_type":"Other"}]},"item_5_description_37":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"text","subitem_description_type":"Other"}]},"item_5_description_41":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_5_source_id_22":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0911-1425","subitem_source_identifier_type":"PISSN"}]},"item_5_text_44":{"attribute_name":"ID(XooNIps)","attribute_value_mlt":[{"subitem_text_value":"2007133062"}]},"item_5_text_54":{"attribute_name":"閲覧数(XooNIps)","attribute_value_mlt":[{"subitem_text_value":"1557"}]},"item_5_text_55":{"attribute_name":"ダウンロード数(XooNIps)","attribute_value_mlt":[{"subitem_text_value":"691"}]},"item_5_text_7":{"attribute_name":"著者 ローマ字","attribute_value_mlt":[{"subitem_text_value":"Nochi, Hitoshi"},{"subitem_text_language":"en","subitem_text_value":"Abe, Satomi"},{"subitem_text_language":"en","subitem_text_value":"Kobayashi, Hiroshi"},{"subitem_text_language":"en","subitem_text_value":"Maeda, Tatsunori"},{"subitem_text_language":"en","subitem_text_value":"Matsuno,Takeo"},{"subitem_text_language":"en"}]},"item_5_version_type_38":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"能地, 仁","creatorNameLang":"ja"},{"creatorName":"ノチ, ヒトシ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"3339","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"阿部, 里見","creatorNameLang":"ja"},{"creatorName":"アベ, 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