2026-03-08T11:03:32Z https://asahikawa-med.repo.nii.ac.jp/oai

oai:asahikawa-med.repo.nii.ac.jp:00004001 2024-07-26T09:03:30Z 7 7:23

Combination of Antihypertensive Therapy in The Elderly, Multicenter Investigation (CAMUI) Trial 佐藤, 伸之 サトウ, ノブユキ Saijo, Yasuaki Hasebe, Naoyuki Antihypertensive agents Combination therapy Cognitive function Angiotensin receptor blockers (ARBs) with calcium channel blockers (CCBs) or diuretics are a widely used combination therapy for hypertensive patients. The present study aimed to determine which combination was better for elderly hypertension patients aged ≧ 65 years. We designed a multicentre, randomized, open-label, parallel comparison study. Hypertensive outpatients aged ≧ 65 years who did not achieve the target blood pressure (BP < 140/90 mmHg) with usual dosages of ARBs were randomly assigned to switch treatment to losartan 50 mg/hydrochlorothiazide 12.5 mg or amlodipine 5 mg in addition to ARBs. The primary endpoint was a change in the systolic blood pressure (SBP) and diastolic blood pressure (DBP) after the 3-month treatment period, while secondary endpoints were changes in the BP, albuminuria, laboratory values, and cognitive function with the mini-mental state examination (MMSE) at baseline and after one year. The results from the CAMUI trial should provide new evidence for selecting optimal combination therapies for elderly hypertensive patients. 雑誌掲載版 J-STAGE掲載版使用 https://www.jstage.jst.go.jp/browse/-char/ja text application/pdf journal article 2012-08-01 VoR application/pdf International Heart Journal 4 53 244 248 1349-2365 https://asahikawa-med.repo.nii.ac.jp/record/4001/files/4746.pdf https://asahikawa-med.repo.nii.ac.jp/records/4001 eng