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Target-controlled infusion and population pharmacokinetics of landiolol hydrochloride in gynecologic patients. 国沢, 卓之 クニサワ, タカユキ 山岸, 昭夫 ヤマギシ, アキオ 須野, 学 スノ, マナブ 中出, 進 ナカデ, ススム 東, 龍之介 ヒガシ, リュウノスケ 黒澤, 温 クロサワ, アツシ 菅原, 亜美 スガワラ, アミ 松原, 和夫 マツバラ, カズオ 岩崎, 寛 イワサキ, ヒロシ Landiolol hydrochloride Pharmacokinetics Target-controlled infusion http://link.springer.com/article/10.1007%2Fs00540-014-1908-5 | http://link.springer.com/article/10.1007%2Fs00540-014-1908-5 PMID:25186494 PURPOSE: \nWe previously determined the pharmacokinetic (PK) parameters of landiolol in healthy male volunteers. In this study, we evaluated the usefulness of target-controlled infusion (TCI) of landiolol hydrochloride and determined PK parameters of landiolol in gynecologic patients. METHODS: \nNine patients who were scheduled to undergo gynecologic surgery were enrolled. After inducing anesthesia, landiolol hydrochloride was administered at the target plasma concentrations of 500 and 1,000 ng/mL for each 30 min. A total of 126 data points of plasma concentration were collected from the patients and used for the population PK analysis. Furthermore, a population PK model was developed using the nonlinear mixed-effect modeling software. RESULTS: \nThe patients had markedly decreased heart rates (HRs) at 2 min after the initiation of landiolol hydrochloride administration; however, their blood pressures did not markedly change from the baseline value. The concentration time course of landiolol was best described by a 2-compartment model with lag time. The estimate of PK parameters were total body clearance (CL) 34.0 mL/min/kg, distribution volume of the central compartment (V 1) 74.9 mL/kg, inter-compartmental clearance (Q) 70.9 mL/min/kg, distribution volume of the peripheral compartment (V 2) 38.9 mL/kg, and lag time (ALAG) 0.634 min. The predictive performance of this model was better than that of the previous model. CONCLUSION: \nTCI of landiolol hydrochloride is useful for controlling HR, and the PK parameters of landiolol in gynecologic patients were similar to those in healthy male volunteers and best described by a 2-compartment model with lag time. text application/pdf 2015-04-01 eng journal article AM https://asahikawa-med.repo.nii.ac.jp/records/5481 10.1007/s00540-014-1908-5 0913-8668 Journal of Anesthesia 29 2 198 205 https://asahikawa-med.repo.nii.ac.jp/record/5481/files/6181.pdf application/pdf 5.0 MB 2021-07-06