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Reticulocyte hemoglobin equivalent as a potential marker for diagnosis of iron deficiency 土岐, 康通 トキ, ヤスミチ 生田, 克哉 イクタ, カツヤ 河原, 好絵 カワハラ, ヨシエ 新関, 紀康 ニイゼキ, ノリヤス 今, 昌幸 コン, マサユキ 榎本, 基樹 エノモト, モトキ 多田, 裕子 タダ, ユウコ 畑山, 真弓 ハタヤマ, マユミ 山本, 昌代 ヤマモト, マサヨ 伊藤, 巧 イトウ, サトシ 進藤, 基博 シンドウ, モトヒロ 菊地, 陽子 キクチ, ヨウコ 井上, 充貴 イノウエ, ミツタカ 佐藤, 一也 サトウ, カズヤ 藤谷, 幹浩 フジヤ, ミキヒロ 奥村, 利勝 オクムラ, トシカツ Reticulocyte hemoglobin equivalent (RET-He) Iron deficiency anemia Iron Iron deficiency Diagnosis PMID：28299633 Evaluation of parameters relating to serum ferritin and iron is critically important in the diagnosis of iron deficiency anemia (IDA). The recent development of automated systems for hematology analysis has made it possible to measure reticulocyte hemoglobin equivalent (RET-He), which is thought to reflect iron content in reticulocytes, in the same sample used for complete blood count tests. If RET-He is, indeed, capable of evaluating iron deficiency (ID), it would be useful for immediate diagnosis of IDA. In the present study, we examined the usefulness of RET-He for diagnosis of ID. Blood samples were obtained from 211 patients. Anemia was defined as hemoglobin (Hb) level of <12 g/dL. Iron deficiency was defined as serum ferritin level of <12 ng/mL. Patients were classified into four groups: IDA, ID, control, and non-ID with anemia. Patients in the IDA group had significantly lower RET-He levels than those in the control group. RET-He correlated with serum ferritin in the IDA and ID groups. The area under the curve for RET-He was 0.902, indicating that RET-He facilitates the diagnosis of ID with high accuracy. RET-He changed in parallel with changes in Hb during iron administration for 21 IDA patients. Our results indicate that RET-He may be a clinically useful marker for determining ID in the general population. text application/pdf 2017-07-01 eng journal article AM https://asahikawa-med.repo.nii.ac.jp/records/5924 10.1007/s12185-017-2212-6 0925-5710 International Journal of Hematology 106 1 116 125 https://asahikawa-med.repo.nii.ac.jp/record/5924/files/7021.pdf application/pdf 9.2 MB 2021-07-06